Gene

mib2

ID

ZDB-GENE-050628-1

Name

MIB E3 ubiquitin protein ligase 2

Symbol

mib2 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Exhibits identical protein binding activity. Contributes to ubiquitin-protein transferase activity. Involved in several processes, including melanocyte differentiation; protein autoubiquitination; and regulation of receptor internalization. Localizes to cytoplasmic vesicle and perinuclear region of cytoplasm. Is expressed in inner ear; mesenchyme pectoral fin; and pectoral fin. Orthologous to human MIB2 (mindbomb E3 ubiquitin protein ligase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Mikami et al., 2015
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mib2 Human Ortholog

No data available

Associated With mib2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000433	Zinc finger, ZZ-type
Domain	IPR001841	Zinc finger, RING-type
Domain	IPR010606	Mib-herc2
Domain	IPR040847	Mind bomb, SH3 repeat domain
Domain	IPR042056	E3 ubiquitin-protein ligase MIB1/2, zinc finger, ZZ-type
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR036770	Ankyrin repeat-containing domain superfamily
Homologous_superfamily	IPR037252	Mib/herc2 domain superfamily
Homologous_superfamily	IPR043145	Zinc finger, ZZ-type superfamily
Repeat	IPR002110	Ankyrin repeat

Domain Details Per Protein

Protein	Length	Ankyrin repeat	Ankyrin repeat-containing domain superfamily	E3 ubiquitin-protein ligase MIB1/2, zinc finger, ZZ-type	Mib-herc2	Mib/herc2 domain superfamily	Mind bomb, SH3 repeat domain	Zinc finger, RING/FYVE/PHD-type	Zinc finger, RING-type	Zinc finger, ZZ-type	Zinc finger, ZZ-type superfamily
UniProtKB:A0AR23 InterPro	999

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	mib2-201 (1) Ensembl	Ensembl		2,670 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations